Fig. 2.
Comparative ligandomics to identify Scg3 as a disease-selective ligand. a Ligandomics globally maps cell-wide endothelial ligands with simultaneous binding activity quantification in live mice. b Quantitative comparison of the entire ligandome profiles for diabetic vs. healthy retina systematically identifies disease-associated endothelial ligands. c Comparative ligandomics identified Scg3 as a diabetes-high ligand, HRP-3 as a diabetes-low ligand and VEGF as a diabetes-unchanged ligand in 4-month-diabetic mice in terms of their preferential endothelial-binding activity. ***p < 0.0001, χ 2 test, diabetic vs. healthy