Table I.

Parameters estimated for CMDRM-MRT, FMDRM-MRT and MDRM using EMR and FAERS dataset. {π₁, π₂, π₃, π₄, π₅, π₆} are the proportions of 2 way to 6 way drug combinations that follow drug-count response component. c is the maximum Myopathy risk.

a.
Dataset	EMR
Parameter	CMDRM-MRT [95%CI]	FMDRM-MRT [95% CI]	MDRM [95% CI]
π1	-	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
π2	0.667 [0.564, 0.770]	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
π3	0.726 [0.683, 0.768]	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
π4	0.823 [0.801, 0.845]	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
π5	0.904 [0.890, 0.919]	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
π6	0.937 [0.920, 0.952]	0.869 [0.858, 0.880]	0.929 [0.920, 0.939]
c	0.448 [0.441, 0.456]	0.460 [0.443, 0.478]	-
β0	−1.084 [−1.107, −1.060]	−1.120 [−1.168, −1.072]	−2.269 [−2.284, −2.254]
β1	0.843 [0.820, 0.866]	0.810 [0.767, 0.853]	−1.908 [−1.926, −1.889]
β2	-	-	0.304 [0.298, 0.309]

b.
Dataset	FAERS
Parameter	CMDRM-MRT [95% CI]	FMDRM-MRT [95% CI]	MDRM [95% CI]
π1	-	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
π2	0.532 [0.423, 0.641]	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
π3	0.781 [0.742, 0.821]	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
π4	0.808 [0.788, 0.827]	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
π5	0.790 [0.778, 0.803]	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
π6	0.803 [0.793, 0.813]	0.798 [0.791, 0.805]	0.675 [0.667, 0.684]
c	0.999 [0.989, 1.000]	0.999 [0.991, 1.000]	-
β0	−2.554 [−2.567, −2.541]	−2.562 [−2.579, −2.546]	−1.594 [−1.605, −1.583]
β1	0.695 [0.691, 0.699]	0.697 [0.693, 0.700]	−3.874 [−3.886, −3.862]
β2	-	-	0.881 [0.877, 0.884]