Table II.
Common 6-way drug combinations detected by CMDRM-MRT with the condition of lfdr<0.00001. RR is the relative risk, it is calculated as risk/constant risk.
| a. | |||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Database | EMR | ||||||
|
| |||||||
| Drug1 | Drug2 | Drug3 | Drug4 | Drug5 | Drug6 | Risk [95% CI] | RR |
| atorvastatin | omeprazole | zolpidem | acetaminophen | hydrocodone | duloxetine | 0.73 [0.47, 0.99] | 6.64 |
| simvastatin | venlafaxine | zolpidem | acetaminophen | hydrocodone | tramadol | 0.59 [0.36, 0.82] | 5.36 |
| simvastatin | venlafaxine | omeprazole | acetaminophen | hydrocodone | duloxetine | 0.56 [0.32, 0.80] | 5.09 |
| ondansetron | omeprazole | promethazine | acetaminophen | hydrocodone | alprazolam | 0.38 [0.23, 0.53] | 3.45 |
| ondansetron | omeprazole | promethazine | acetaminophen | alprazolam | oxycodone | 0.43 [0.25, 0.61] | 3.91 |
| escitalopram | omeprazole | zolpidem | acetaminophen | oxycodone | duloxetine | 0.69 [0.44, 0.94] | 6.27 |
| b. | |||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Database | FAERS | ||||||
|
| |||||||
| Drug1 | Drug2 | Drug3 | Drug4 | Drug5 | Drug6 | Risk [95%CI] | RR |
| atorvastatin | omeprazole | zolpidem | acetaminophen | hydrocodone | duloxetine | 0.63 [0.49, 0.76] | 9.00 |
| simvastatin | venlafaxine | zolpidem | acetaminophen | hydrocodone | tramadol | 0.70 [0.53, 0.87] | 10.00 |
| simvastatin | venlafaxine | omeprazole | acetaminophen | hydrocodone | duloxetine | 0.76 [0.58, 0.94] | 10.85 |
| ondansetron | omeprazole | promethazine | acetaminophen | hydrocodone | alprazolam | 0.48 [0.36, 0.60] | 6.85 |
| ondansetron | omeprazole | promethazine | acetaminophen | alprazolam | oxycodone | 0.43 [0.30, 0.56] | 6.14 |
| escitalopram | omeprazole | zolpidem | acetaminophen | oxycodone | duloxetine | 0.71 [0.61, 0.81] | 10.14 |