Table 3.

Summary of SNPs with FDR Q ≤ 0.2 for tests of maternal genetic effects, adjusting for child genotype, and child genetic effects, adjusting for maternal genotype for preeclampsia overall.

							Mother			Child			Joint test
Markera	Chr	Position	MAF Mother	MAF Child	Gene	Genotype	RR (95% CI)	P value	FDR Q value	RR (95% CI)	P value	FDR Q value	P value	FDR Q value
rs7435347	4	156654735	0.17	0.17	GUCY1A3	AA	Referent	6.17 × 10−4	0.09	Referent	0.09	0.76	3.36 × 10−3	0.30
						GA	1.47 (1.20, 1.80)			0.83 (0.69, 0.99)
						GG	1.00 (0.63, 1.58)			0.67 (0.40, 1.14)
rs1569788	6	152328616	0.30	0.30	ESR1	TT	Referent	3.02 × 10−4	0.09	Referent	0.61	0.88	2.66 × 10−3	0.30
						CT	0.70 (0.58, 0.84)			1.07 (0.89, 1.28)
						CC	0.93 (0.67, 1.30)			1.18 (0.83, 1.68)
rs3020366	6	152368758	0.37	0.36	ESR1	TT	Referent	5.45 × 10−4	0.09	Referent	0.40	0.88	4.49 × 10−3	0.30
						CT	0.70 (0.58, 0.84)			1.11 (0.92, 1.32)
						CC	0.86 (0.64, 1.15)			1.23 (0.90, 1.67)
rs6462324	7	32120897	0.40	0.39	PDE1C	CC	Referent	2.05 × 10−4	0.09	Referent	0.32	0.88	1.23 × 10−3	0.25
						AC	0.69 (0.57, 0.84)			1.04 (0.87, 1.25)
						AA	0.93 (0.69, 1.23)			1.24 (0.92, 1.69)
rs6470860	8	131905190	0.41	0.42	ADCY8	AA	Referent	0.96	0.98	Referent	3.12 × 10−4	0.15	9.88 × 10−5	0.07
						GA	1.03 (0.85, 1.24)			1.32 (1.10, 1.58)
						GG	1.02 (0.77, 1.35)			1.85 (1.36, 2.51)
rs12547243	8	131921956	0.29	0.31	ADCY8	GG	Referent	0.09	0.89	Referent	2.69 × 10−5	0.04	6.27 × 10−7	8.78 × 10−4
						AG	1.14 (0.94, 1.37)			1.41 (1.19, 1.67)
						AA	0.82 (0.58, 1.17)			2.12 (1.46, 3.07)
rs7459573	8	131928401	0.34	0.36	ADCY8	AA	Referent	0.92	0.98	Referent	1.61 × 10−4	0.11	3.14 × 10−4	0.11
						GA	0.97 (0.81, 1.17)			1.43 (1.20, 1.70)
						GG	0.94 (0.69, 1.28)			1.73 (1.25, 2.38)
rs17475920	12	18478126	0.12	0.13	PIK3C2G	AA	Referent	9.39 × 10−4	0.10	Referent	0.13	0.80	7.12 × 10−3	0.34
						TA	1.52 (1.21, 1.90)			0.85 (0.69, 1.04)
						TT	1.65 (0.80, 3.40)			0.54 (0.27, 1.07)
rs9634063	12	18593252	0.15	0.15	PIK3C2G	CC	Referent	2.70 × 10−4	0.09	Referent	0.04	0.76	1.95 × 10−3	0.30
						TC	1.54 (1.25, 1.91)			0.80 (0.66, 0.97)
						TT	1.39 (0.75, 2.60)			0.56 (0.30, 1.06)

^aSNPs that also met Q ≤ 0.2 and were in high linkage disequilibrium (R² > 0.8 using 1000 Genomes Pilot 1 CEU data): rs3796578 (R² = 1.0 with rs7435347); rs722208 (R² = 1.0 with rs1569788); rs3020365 (R² = 0.93 with rs3020366); rs11044095, rs1447406, rs11044129, rs7311726, rs1447408 (R² ≥ 0.92 with rs9634063)