Table 4.

Summary of SNPs with FDR Q ≤ 0.2 for tests of maternal genetic effects, adjusting for child genotype, and child genetic effects, adjusting for maternal genotype for preeclampsia subtypes.

							Mother			Child			Joint test
Marker*	Chr	Position	MAF Mother	MAF Child	Gene	Genotype	RR (95% CI)	P value	FDR Q value	RR (95% CI)	P value	FDR Q value	P value	FDR Q value
Severe Preeclampsia
No SNPs with Q ≤ 0.2
Early-onset preeclampsia (diagnosis <34 weeks)
No SNPs with Q ≤ 0.2
Preeclampsia with delivery <34 weeks
rs30593	7	32105096	0.35	0.35	PDE1C	CC	Referent	1.69 × 10−5	0.02	Referent	0.40	0.75	5.38 × 10−5	0.07
						TC	0.45 (0.27, 0.75)			0.63 (0.31, 1.30)
						TT	1.44 (0.63, 3.30)			0.89 (0.27, 2.89)
rs12785615	11	106869624	0.14	0.14	GUCY1A2	GG	Referent	6.32 × 10−4	0.20	Referent	0.66	0.75	2.80 × 10−3	0.62
						CG	0.63 (0.35, 1.15)			0.85 (0.35, 2.08)
						CC	4.31 (1.42, 13.10)			--
rs1455590	11	106869973	0.23	0.23	GUCY1A2	GG	Referent	3.50 × 10−4	0.15	Referent	0.44	0.75	6.10 × 10−4	0.34
						AG	0.63 (0.38, 1.03)			1.43 (0.73, 2.80)
						AA	2.50 (1.16, 5.37)			0.65 (0.07, 5.70)
rs11636443	15	52319696	0.44	0.44	MAPK6	GG	Referent	3.17 × 10−4	0.15	Referent	0.21	0.75	1.89 × 10−3	0.62
						AG	0.68 (0.42, 1.08)			0.55 (0.27, 1.11)
						AA	1.98 (0.97, 4.02)			0.47 (0.17, 1.32)
Preeclampsia with small for gestational age
rs30562	7	32065264	0.35	0.35	PDE1C	CC	Referent	0.04	0.96	Referent	4.42 × 10−5	0.06	2.76 × 10−5	0.04
						TC	1.40 (1.04, 1.88)			0.50 (0.36, 0.71)
						TT	1.04 (0.62, 1.73)			1.02 (0.62, 1.70)