Table 3.

Correlation of Genomic and Histo-Pathological Measures of Malignancy with the Diagnostic and Revised Gleason Scores

			SCORE
Measure	Diagnostic Gleason		Revised Gleason
	Correlation	p-value	Correlation	p-value
Clonal Heterogeneity	0.36 (-0.43)	0.26 (0.35)	0.86 (0.76)	0.01 (0.11)
Proportion of clonal cells	0.46 (-0.12)	0.14 (0.8)	0.79 (0.63)	0.01 (0.16)
Proportion of clonal features	0.55 (0.12)	0.08 (0.8)	0.79 (0.63)	0.01 (0.16)
Proportion of sectors with clonality	0.55 (0.12)	0.08 (0.8)	0.79 (0.63)	0.01 (0.16)
Clonal spread	0.55 (0.12)	0.08 (0.8)	0.79 (0.63)	0.01 (0.16)
Proportion of sectors with pathology	0.71 (0.36)	0.02 (0.4)	0.7 (0.32)	0.03 (0.5)
Highest Involvement of Cancer	0.83 (0.67)	0.01 (0.14)	0.78 (0.53)	0.02 (0.3)
Mean Involvement of Cancer	0.8 (0.6)	0.01 (0.17)	0.7 (0.32)	0.03 (0.5)
Diagnostic Gleason Score	1 (1)	0.002 (0.03)	0.64 (0)	0.06 (0.1)

Summary of the correlations of genomic and histo-pathological measures of malignancy with the diagnostic and revised Gleason scores. Tabulated are Kendall rank correlations and the corresponding p-values for each measure and each Gleason score, computed for the eight diagnostic biopsy cases in Table 1. The values in parentheses correspond to the five diagnostic biopsy cases for which histo-pathological evaluation of a resected prostate is available.