Figure 3. Down-regulated insulin signaling-related mRNAs in MetS-MSC.
(a) Downregulated mRNAs in MetS-MSC were mainly involved in functions associated with the membrane. (b) Cellular localization of down-regulated mRNAs revealed primarily the extracellular region and membrane of the cell. (c) Many down-regulated mRNAs with the highest fold change (Lean-MSC/MetS-MSC) account for proteases and proteins involved in calcium flux. (d) Heat map of the top 40 down-regulated mRNAs showing a decreased abundance in MetS-MSC.