Figure 1.

Localization of cortical ECoG strip and cortical signals used for analysis (A) registration of pre-operative structural high resolution T1 weighted MRI and CT to co-localize cortical brain surface and skull (B) Tips of the stereotactic frame and DBS leads (marked by + signs and straight red and blue lines on the image, respectively) are used as landmarks to complete 2D-3D fusion of fluoroscopic image and cortical surface. Once the fusion is complete cortical contacts (visible on the fluoroscopic image) are marked manually on the fused images. (C) Marked ECoG contacts are shown on cortical surface and identified relative to the central sulcus. (D) Three cortical bipolar signals spanning post to pre central gyri/sensorimotor cortices (posterior to anterior: PostCS, CS and PreCS) are marked and used for all of the analyses. (For more detailed description of the registration method please refer to the online supplementary digital content)