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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Magn Reson Med. 2017 Jul 17;79(4):2346–2358. doi: 10.1002/mrm.26831

Table 3.

AUC of the ROC Curves for Discriminating Normal and Tumor Tissue for Each Prostatic Zone and Model Parameter, Including Combined Model Parameters.a

AUC
Cutoff value
r/r′
Model Parameter b-Factors [s/mm2] PZ (nN=56, nT=27) TZ (nN=55, nT= 13) PZ (nN=56, nT= 27) TZ (nN=55, nT= 13) PZ (nN=56, nT=27) TZ (nN=55, nT=13)
Monoexponential ADC 0–1250 0.95 ±0.03 0.97 ±0.03 1.66 1.49 – –
250–1250 0.94 ±0.03 0.95 ±0.04 1.37 1.08 – –
Biexponential fslow + r·Dslow + r·′Dfast 0–3500 0.95 ±0.03 0.97 ±0.03 0.00 −0.05 −0.20/−0.07 −1.54/0.11
250–3500 0.94 ±0.03 0.97 ±0.03 −0.27 0.10 0.09/−0.22 −1.61/0.18
fslow + r·Dslow 0–3500 0.94 ±0.03 0.97 ±0.03 0.05 −0.06 −0.45 −0.85
250–3500 0.93 ±0.03 0.93 ±0.05 0.08 0.01 −0.34 −0.69
fslow + r·Dfast 0–3500 0.94 ±0.03 0.91 ±0.06 −0.06 0.23 −0.13 −0.04
250–3500 0.94 ±0.03 0.88 ±0.06 −0.19 −0.49 −0.18 −0.39
fslow 0–3500 0.90 ±0.04 0.88 ±0.06 0.24 0.36 – –
250–3500 0.91 ±0.04 0.87 ±0.07 0.20 0.30 – –
Dslow + r·Dfast 0–3500 0.81 ±0.06 0.95 ±0.04 0.47 0.20 0.01 −0.09
250–3500 0.84 ±0.05 0.91 ±0.06 −2.24 0.12 −1.15 −0.10
Dslow 0–3500 0.80 ±0.06 0.86 ±0.07 0.44 0.43 – –
250–3500 0.72 ±0.06 0.88 ±0.06 0.32 0.34 – –
Dfast 0–3500 0.73 ±0.06 0.60 ±0.09 2.65 2.58 – –
250–3500 0.83 ±0.05 0.77 ±0.08 2.24 2.15 – –
fperfusion –   0.52 ±0.07 0.62 ±0.09 0.08 0.05
Kurtosis ADCK 0–3500 0.95 ±0.03 0.97 ±0.04 1.88 1.67 – –
250–3500 0.95 ±0.03 0.96 ±0.04 1.64 1.32 – –
K 0–3500 0.92 ±0.04 0.95 ±0.04 0.55 0.60 – –
250–3500 0.89 ±0.04 0.88 ±0.06 0.58 0.66 – –
Stretched exponential DDC 0–3500 0.93 ±0.04 0.97 ±0.04 1.71 1.47 – –
250–3500 0.72 ±0.06 0.80 ±0.08 8.46 5.06 − −
Mode 0–3500 0.91 ±0.04 0.96 ±0.04 0.63 0.62 – –
250–3500 0.85 ±0.05 0.81 ±0.08 0.97 0.65 – –
α 0–3500 0.66 ±0.07 0.68 ±0.09 0.67 0.66 – –
250–3500 0.52 ±0.07 0.65 ±0.09 0.47 0.46 – –
Gamma Mode: (k−1)·θ 0–3500 0.92 ±0.04 0.95 ±0.04 1.02 1.00 – –
 distribution 250–3500 0.96 ±0.04 0.88 ±0.06 1.07 0.91 – –
k + r· θ 0–3500 0.89 ±0.04 0.98 ±0.03 2.71 2.67 0.67 0.73
250–3500 0.87 ±0.05 0.86 ±0.07 2.36 1.70 0.42 0.09
k 0–3500 0.85 ±0.05 0.90 ±0.06 1.59 1.33 – –
250–3500 0.79 ±0.06 0.84 ±0.07 1.49 1.58 – –
θ 0–3500 0.60 ±0.07 0.55 ±0.09 1.55 1.32 – –
250–3500 0.60 ±0.07 0.66 ±0.09 1.18 1.38 – –
a

AUC data are given as mean ± standard deviation (20).

Units for diffusion coefficients, θ, and Mode are μm2/ms.

nN = number of normal tissue ROIs; nT = number of tumor tissue ROIs.