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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Hepatology. 2018 Jan 26;67(3):955–971. doi: 10.1002/hep.29371

Figure 4. FXR and RXRα binding to the SHP promoter increases after BDL in KO livers, concomitant with increased transcriptional activation.

Figure 4

(A) ChIP assay for FXR shows a significant increase in SHP occupancy in KO after BDL compared to both KO at baseline or WT after BDL. (B) ChIP for RXRα also shows increased occupancy of SHP promoter in KO compared to WT after BDL. (C) ChIP for TCF4 shows decreased occupancy of SHP after BDL in both WT and KO. (D) Transcriptional activity of SHP, as assessed by ChIP for H4K5Ac, is increased in KO before and after BDL compared to WT. *p<0.05 vs. sham WT, #p<0.05 vs. sham KO, %p<0.05 vs. BDL WT.