Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of Action and Biological Features Triggered by the Oncolytic Vector WR-Δ4
The VACV-based oncolytic vector WR-Δ4 combines four deletions (A48R, B18R, C11R, and J2R) that result in reduced virulence in healthy tissues (increased safety) and an anti-tumor response through infection and replication in tumor cells (with associated release of cytokines, chemokines, danger signals, and tumor-associated antigens), and stimulate innate and adaptive (TAA-specific) immune responses.
