Table 1.
Studies included in the systematic review
| No. | Author | Year | Study design | Indication (FDA) | Graft | Region |
|---|---|---|---|---|---|---|
| 1 | Cochran et al. | 2000 | MRCT | In label | rhBMP/2 + ACS | Fresh alveolous |
| 2 | Jung et al. | 2003 | RCCT | Off label | rhBMP-2 + XG + CM | Vestibular dehiscence |
| 3 | Fiorellini et al. | 2005 | MRCT | In label | rhBMP-2 + ACS | Fresh alveolous |
| 4 | Boyne et al. | 2005 | MRCCT | In label | rhBMP-2 + ACS | Maxillary sinus |
| 5 | Triplett et al. | 2009 | MRCCT | In label | rhBMP-2 + ACS | Maxillary sinus |
| 6 | de Freitas et al. | 2013 | RCT | Off label | rhBMP-2 + ACS + TM | Horizontal maxillary ridge reconstruction |
| 7 | Marx et al. | 2013 | ECR | Off label | rhBMP-2 + AG + PRP + TM | Horizontal and vertical maxillary ridge reconstruction |
| 8 | Coomes et al. | 2014 | RCCT | In label | rhBMP-2 + ACS | Fresh alveolous |
| 9 | Misch et al. | 2015 | RCS | Off label | rhBMP-2 + ACS + AG + TM | Horizontal and vertical maxillary and mandible ridge reconstruction |
MRCT multicentric randomized clinical trial, RCCT randomized controlled clinical trial, MRCCT multicentric randomized controlled clinical trial, RCT randomized clinical trial, RCS retrospective clinical study, XG xenogenous graft, CM collagenous membrane; TM titanium mesh, AG allogenous graft, PRP platelet rich plasma