Table 6.
Data from studies reporting adverse effects and complications in reconstructions with rhBMP-2
| Author | Edema | Erythema | Pain | Immune response | Systemic | Infection | Dehiscence/membrane exposure | Total of events per study |
|---|---|---|---|---|---|---|---|---|
| Cochran et al. | − | + | + | − | + | + | − | 21 |
| Jung et al. | − | − | − | − | − | − | + | 1 |
| Fiorellini et al. | + | + | + | + | − | − | − | 250 |
| Boyne et al. | + | + | + | + | + | − | + | 546 |
| Triplett et al. | + | − | + | + | − | − | − | NI |
| Freitas et al. | + | + | + | − | − | − | + | NI |
| Marx et al. | + | − | − | − | − | + | + | NI |
| Coomes et al. | + | + | − | − | − | − | − | NI |
| Misch et al. | − | − | − | − | − | − | − | NI |
| Total studies | 6 | 5 | 5 | 3 | 2 | 2 | 4 | 818 |
+ present, − absent, NI not informed