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. 2018 Jan 17;9:263. doi: 10.1038/s41467-017-02499-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Experimental design and ZIKV infection relative to fetal brain development. The pregnant dams were infected with ZIKV at 31, 51, 114, and 115 dGA. For all animals, C-section delivery was performed at 135dGA and maternal and fetal tissues were collected. Maternal peripheral blood, urine, and saliva samples (red asterisks) were obtained at the times indicated. Ultrasound analyses of the fetus and placenta were performed at the times indicated with gray asterisks