Fig. 5.

Uteroplacental histopathology of ZIKV-infected cases compared with gestational-age-matched negative controls. a All five ZIKV-infected cases showed placental infarctions (asterix) with large gross infarctions seen in the cases infected at days 31–51. b ZIKV cases had conspicuous villous stromal calcifications (arrows), which are a consequence of stromal fibroblast cell death (c). ZIKV cases were positive for chronic decidualitis with plasma cells and lymphoplasmacytic leuokocytoclastic vasculitis (d), which was associated damage to the uterine spiral arteries (e) and vascular luminal (astericks) narrowing (f). Scale bar is 100 µm