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. 2018 Jan 17;9:263. doi: 10.1038/s41467-017-02499-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Cortical surface model and apparent diffusion coefficient (ADC) map of fetal brains. For animal F35467, a 3D cortical surface model was generated and curvature of the cortical surface was rendered on the surface (a, top, lateral view; bottom, dorsal view). Compared to an age-matched control (b), a significantly thinner postcentral gyrus, especially at the dorsal portion, can be detected (a, arrows). A missing secondary sulcus (b, asterisks) was also identified on the postcentral gyrus of animal F35467. c An ADC map generated from 8 control fetuses at gestation age 135dGA ± 2d and d one ADC map from ZIKV animal F35797 are shown at 4 axial slices at indicated levels (inset). Lower ADC is observable on the right hemisphere at the regions of motor, somatosensory, as well as auditory cortices compared to the left hemisphere (red dashed circles)