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. 2018 Jan 17;8:949. doi: 10.1038/s41598-018-19264-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The oxygen consumption rate (OCR) of the Mt iPS cell clones measured using an XF96 Extracellular Flux Analyzer. Representative data for the Mt1 iPS cell clones are shown as follows: (a) time course (open circle, Mt1-1^low; open square, Mt1-2^low; closed circle, Mt1-3^high; closed square, Mt1-4^high), (c) basal OCR, (d) ATP production, (e) spare respiratory capacity, and (f) proton leak. Representative data for the Mt2 iPS cell clones are shown as follows: (b) time course (open circle, Mt2-3^low; open square, Mt2-8^low; closed square, Mt2-6^high; closed circle, Mt2-5^high), (g) basal OCR, (h) ATP production, (i) spare respiratory capacity, and (j) proton leak. OCR was normalized to total protein and is expressed as the mean ± SD. n = 4–5. **P < 0.01 and *P < 0.05, ANOVA with a post hoc test (Tukey’s test).