. 2018 Jan 17;8:975. doi: 10.1038/s41598-017-18457-w

Table 3.

Summary of IC₅₀ values for drugs, species and assays.

Species, Assay & Treatment Duration	IC₅₀ (μM)
Species, Assay & Treatment Duration	Sertraline	Paroxetine	Chlorpromazine
*C. elegans*
Lethality (48 h)^a	18.2*	71.6*	133.2*
Motility (24 h)^a	8.8 ^ns	12.3 ^ns	13.3 ^ns
Pumping inhibition (60 min)^b	52*	123^ns	108^ns
*T. muris*
Motility (1 h)^c	38.4*	207.6^ns	89.5^ns
Motility (24 h)^c	7.2^ns	5.4^ns	0.7*
*A. caninum*
Hatching (24 h)^d	4.3*	6.4^ns	6.1^ns
Developing/hatched (24 h)^d	7.0**	10.4^ns	8.1^ns
*S. mansoni*
Motility (24 h)^e	8.4 ^ns	7.5 ^ns	ND

Source of data: ^aFig. 1; ^bFig. 2; ^cFig. 3; ^dFig. 4; ^eFig. 6. Underline indicates the drug(s) with the lowest IC₅₀ for each test. *Differs significantly from other values in same row; ^nsvalues do not differ significantly from other values labeled “ns” in same row; **differs significantly from paroxetine but not chlorpromazine. ND, not determined; an IC₅₀ value could not be calculated.