Table 2.

Concentrations and mean percent change of different metabolites before (T0) and 6 months after (T1) successful interventional LAAC

Metabolite	T0 (µM)	T1 (µM)	Percent change	p value
Asymmetric dimethylarginine (ADMA)	0.55 ± 0.14	0.55 ± 0.15	1.09 ± 2.37	0.87
Alanine (Ala)	307.05 ± 102.32	338.19 ± 107.43	10.14 ± 3.98	0.047
Arginine (Arg)	66.33 ± 17.12	64.82 ± 17.00	−2.28 ± 1.74	0.66
Asparagine (Asn)	39.13 ± 10.18	40.11 ± 14.80	2.50 ± 2.00	0.85
Aspartate (Asp)	5.34 ± 1.70	4.92 ± 1.89	−7.87 ± 3.78	0.049
Citrulline (Cit)	33.77 ± 11.39	37.25 ± 12.65	10.31 ± 2.17	0.09
Glutamine (Gln)	661.5 ± 109.10	646.89 ± 120.87	−2.21 ± 2.02	0.31
Gutamate (Glu)	86.54 ± 51.92	87.14 ± 51.72	0.69 ± 1.24	0.85
Glycine (Gly)	263.89 ± 104.57	226.11 ± 85.56	−14.32 ± 3.52	< 0.001
Hexose	6703.41 ± 1754.89	7920.14 ± 2478.32	18.15 ± 3.15	< 0.001
Ornithin (Orn)	80.63 ± 26.71	86.25 ± 27.88	6.97 ± 2.94	0.13
Proline (Pro)	203.82 ± 54.85	236.55 ± 79.86	16.06 ± 3.76	0.002
Sarcosine	2.29 ± 0.54	2.55 ± 0.59	11.35 ± 2.97	0.002
Symmetric dimethylarginine (SDMA)	0.85 ± 0.46	0.74 ± 0.37	−12.94 ± 3.07	< 0.001
Serine (Ser)	106.98 ± 27.49	95.27 ± 24.86	−10.95 ± 3.91	0.007
Trans 4-hydroxy-Proline (t4-OH-Pro)	11.97 ± 5.22	12.58 ± 5.54	5.10 ± 2.46	0.42

Metabolites appear in alphabetical order. Data are presented as mean concentration ± standard deviation

Statistical significance p < 0.05 is highlighted in bold