Table 1.
Statistical details of age, sex, and interaction effects on MOR binding densities in the rat brain
| Direction | Age effect | Sex effect | Interaction effect | |
|---|---|---|---|---|
| Telencephalon | ||||
| Striatal areas | ||||
| aCPu | F (1,40) = 0.34; p = 0.56 | F (1,40) = 3.52; p = 0.07 | F (1,40) = 0.69; p = 0.41 | |
| CPu | F (1,46) = 0.23; p = 0.63 | F (1,46) = 0.48; p = 0.49 | F (1,46) = 0.03; p = 0.86 | |
| aAcbC | F (1,46) = 0.30; p = 0.59 | F (1,46) = 1.73; p = 0.19 | F (1,46) = 0.22; p = 0.64 | |
| aAcbSh | F (1,46) = 0.19; p = 0.66 | F (1,46) = 1.16; p = 0.29 | F (1,46) = 4.01; p = 0.05 | |
| dmAcbSh | F (1,46) = 0.14; p = 0.71 | F (1,46) = 1.24; p = 0.27 | F (1,46) = 0.68; p = 0.41 | |
| vAcbSh | F (1,46) = 4.59; p = 0.04 | F (1,46) = 0.10; p = 0.75 | F (1,46) = 0.16; p = 0.69 | |
| Septal areas | ||||
| LS | Higher in juveniles and males | F (1,42) = 86.2; p < 0.001 | F (1,42) = 6.73; p = 0.013 | F (1,42) = 1.63; p = 0.21 |
| Bed nucleus of the stria terminalis areas | ||||
| BNSTpm | F (1,45) = 4.32; p = 0.04 | F (1,45) = 0.14; p = 0.71 | F (1,45) = 1.54; p = 0.22 | |
| BNSTp | Higher in juveniles | F (1,41) = 38.29; p < 0.001 | F (1,41) = 0.00; p = 0.95 | F (1,41) = 5.95; p = 0.02 |
| Amygdala areas | ||||
| IPAC | F (1,46) = 0.46; p = 0.50 | F (1,46) = 1.12; p = 0.30 | F (1,46) = 0.05; p = 0.83 | |
| MePD | F (1,46) = 0.93; p = 0.34 | F (1,46) = 0.26; p = 0.61 | F (1,46) = 2.76; p = 0.10 | |
| BLA | F (1,46) = 5.84; p = 0.02 | F (1,46) = 0.04; p = 0.83 | F (1,46) = 0.06; p = 0.80 | |
| PMCO | Higher in females | F (1,46) = 0.38; p = 0.54 | F (1,46) = 9.56; p < 0.005 | F (1,46) = 6.60; p = 0.01 |
| Hippocampal areas | ||||
| CA1 | Higher in juveniles | F (1,46) = 11.0; p < 0.002 | F (1,46) = 0.53; p = 0.47 | F (1,46) = 0.13; p = 0.72 |
| CA2/3 | Higher in juveniles | F (1,46) = 12.5; p < 0.001 | F (1,46) = 1.85; p = 0.18 | F (1,46) = 0.08; p = 0.77 |
| MoDGp | Higher in adults | F (1,40) = 7.02; p = 0.012 | F (1,40) = 0.46; p = 0.50 | F (1,40) = 1.42; p = 0.24 |
| Diencephalon | ||||
| Thalamic areas | ||||
| DLG | Higher in juveniles | F (1,46) = 32.1; p < 0.001 | F (1,46) = 1.83; p = 0.18 | F (1,46) = 0.49; p = 0.49 |
| LDTN | F (1,40) = 0.18; p = 0.67 | F (1,40) = 4.02; p = 0.05 | F (1,40) = 3.16; p = 0.08 | |
| LPTN | Higher in juveniles | F (1,38) = 12.8; p < 0.001 | F (1,38) = 0.39; p = 0.54 | F (1,38) = 1.05; p = 0.31 |
| MDL | F (1,40) = 0.09; p = 0.77 | F (1,40) = 0.25; p = 0.62 | F (1,40) = 0.65; p = 0.42 | |
| Po | Higher in juveniles | F (1,45) = 35.1; p < 0.001 | F (1,45) = 0.09; p = 0.76 | F (1,45) = 6.63; p = 0.01 |
| PV | Higher in juveniles | F (1,40) = 41.4; p < 0.001 | F (1,40) = 1.70; p = 0.20 | F (1,40) = 0.05; p = 0.82 |
| Re | Higher in juveniles | F (1,46) = 84.0; p < 0.001 | F (1,46) = 0.10; p = 0.75 | F (1,46) = 3.07; p = 0.09 |
| Rt | Higher in juveniles | F (1,46) = 26.2; p < 0.001 | F (1,46) = 1.52; p = 0.22 | F (1,46) = 0.02; p = 0.89 |
| sm | F (1,46) = 4.64; p = 0.04 | F (1,46) = 0.23; p = 0.63 | F (1,46) = 0.38; p = 0.54 | |
| Mesencephalon | ||||
| Tectal areas | ||||
| SuG | F (1,46) = 4.39; p = 0.04 | F (1,46) = 2.32; p = 0.13 | F (1,46) = 0.37; p = 0.54 | |
| CIC | F (1,36) = 2.72; p = 0.11 | F (1,36) = 0.40; p = 0.53 | F (1,36) = 0.10; p = 0.75 | |
| DCIC | F (1,46) = 4.66; p = 0.04 | F (1,46) = 1.83; p = 0.18 | F (1,46) = 0.49; p = 0.49 | |
| Tegmental areas | ||||
| LPAG | F (1,39) = 4.56; p = 0.04 | F (1,39) = 0.15; p = 0.70 | F (1,39) = 2.90; p = 0.10 | |
| SNCD | F (1,44) = 3.97; p = 0.05 | F (1,44) = 0.09; p = 0.77 | F (1,44) = 0.12; p = 0.73 | |
| IPA | F (1,42) = 0.57; p = 0.45 | F (1,42) = 0.03; p = 0.87 | F (1,42) = 3.56; p = 0.07 | |
| IPC | Higher in juveniles | F (1,42) = 9.13; p < 0.005 | F (1,42) = 0.30; p = 0.59 | F (1,42) = 2.27; p = 0.14 |
| IPL | Higher in juvenile males | F (1,42) = 5.26; p = 0.03 | F (1,42) = 0.85; p = 0.36 | F (1,42) = 10.1; p < 0.005 |
Significant effects (two-way ANOVA with FDR correction: p < 0.0130) are bolded