FIG 6.

A maximum likelihood tree based on the acyltransferase (AT) proteins of different trans-AT PKS biosynthesis gene clusters. Swinholide-type compounds are clustered together (box). Branch lengths are proportional to sequence change, and bootstrap values above 50% are given at the node. The tree was rooted with cis-AT from enacyloxin gene cluster of Burkholderia ambifaria AMMD (accession no. ABI91466.1). Information about the produced compounds and the accession numbers of the proteins are provided in Table S6 in the supplemental material.