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Performance of BIC-seq2, CNVnator, FREEC and ReadDepth for simulated data. BIC-seq2-Unqiue: only uniquely mapped reads; BIC-seq2-Nonunique: all mapped reads are used, with a randomly sampled position when the reads are multiply-aligned. (A1–A5) At 3X coverage, the sensitivities for (A1) 2-copy deletions, (A2) 1-copy deletions, (A3) 1-copy gains, (A4) 2-copy gains and (A5) 3-copy gains. (B1–B5) and (C1–C5) are similar plots but at 10X and 30X coverages.
