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. 2018 Jan 17;8:968. doi: 10.1038/s41598-018-19213-4

Figure 2.

Figure 2

Effects of various xCT inhibitors on cystine uptake activity in xCT- overexpressing MEF. xCT-overexpressing MEF were cultured for 24 h and then the uptake of 0.05 mM L-[14C]cystine was measured in the presence of various inhibitors at the concentrations indicated. Each point represents the mean ± S.D. (n = 4 for CPG, QA, and Glu; n = 6 for Erastin and SAS). P values were obtained by one-way ANOVA followed by Tukey’s multiple comparison test. *P = 1.8 × 10−2 (erastin vs CPG at 10 µM). ***P = 1 × 10−6 (erastin vs Glu or SAS at 1 µM, erastin vs Glu, SAS, or QA at 10 µM, erastin vs Glu at 100 µM), 6 × 10−6 (erastin vs QA at 1 µM), 4 × 10−4 (erastin vs CPG at 1 µM).