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. 2018 Jan 17;8:992. doi: 10.1038/s41598-018-19368-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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M22 regulates G0/G1 arrest through a negative feedback mechanism. (A) M22 attenuates mRNA expression of Cyclin D1, Cyclin E1, CDK4, CDK6, CDC25A and PCNA genes in A549 cells for 24 h. RNA was isolated and analsis was performed to detect by qRT-PCR. *Means P < 0.01, ***means P < 0.0001. (B) M22 down-regulates the expression of Cyclin D1 and CDC25C protein in A549 cells by Western blotting.