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. 2018 Jan 17;8:992. doi: 10.1038/s41598-018-19368-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of M22 on apoptosis related genes and proteins in A549 cells. (A) M22 upregulated the expression of proapoptotic genes APAF1, CASP9, CASP3, BAX, and depress antiapoptotic genes BCL2 for 48 h. RNA was isolated and analysis was performed to detect by qRT-PCR. *Means P < 0.01, ***means P < 0.0001. (B) Western blot analysis showed cleavage of caspases-9 and −3 in M19 treated A549 cells after 48 h of exposure. Equal loading was confirmed by reprobing the membrane with GAPDH. The bands shown here are from a representative experiment repeated three times with similar results.