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. 2018 Jan 17;8:989. doi: 10.1038/s41598-017-18932-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Transmission electron microscopy images of MSN. Characterization of particles size and (i) morphology and (ii) analysis of pore structure. Scale bar is given. (B) Scheme of particle functionalization with succinic anhydride, antibody (anti-human/mouse-B220 (CD45R) or anti-human-CD9) and fluorescent dye (ATTO 594). (C) B220⁺ AML LSCs (CALM-AF10 cells) were treated with the anti-B220 tagged MSNs particles for 24 hours and spotted on glass slides and were visualized by confocal fluorescence microscopy. Nuclei were stained with DAPI (Blue), GFP (Green) is expressed retrovirally by the cells line and ATTO 594 (Red) was covalently linked to the MSNs. One representative image from three (n = 3) independently performed experiments. Particle concentration used is 50 µg/mL. For the upper and middle panel of images a magnification of 200X was used. The lower panel shows 4X zoomed in areas of the middle panel.