Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 17;8:989. doi: 10.1038/s41598-017-18932-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A) FACS dot plot demonstrating B220 positivity of the B220⁺ AML LSCs after blockage with the unlabeled anti-B220 antibody for 4 hours and subsequent staining with the anti- B220-PE conjugated antibody compared to an unblocked control (n = 3). Cell death of B220⁺ AML LSCs blocked by the anti-B220 antibody after incubation with different concentrations of (B) free daunorubicin (n = 3) or (C) with anti-B220 MSN-DN compared to unblocked cells (n = 3) (p = n.s. and p < 0.001, respectively). (D) Representative FACS dot plot showing expression of the CD9 antigen on B220⁺ AML LSCs (CALM-AF10 cells)(n = 3). (E) Percent death of B220⁺ AML LSCs induced by daunorubicin loaded MSNs at different particle concentrations after 24 hours incubation as indicated (n = 3)(p < 0.01).