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. 2018 Jan 17;8:998. doi: 10.1038/s41598-018-19343-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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JQ1 radiosensitized esophageal cancer and breast cancer cells in vitro. (A) Colony formation assay was performed as described in Materials and Methods. (B). Representative images of colony formation in esophageal cancer Eca109 and breast cancer MCF7 cells treated with 4 Gy irradiation alone or combined with JQ1 (500 nM). (C) The numbers of colonies of Eca109 and MCF7 cells treated with radiation alone or with JQ1. Results were shown as the means ± SD at least three independent experiments. **P < 0.01 vs. Radiation group.