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. 2018 Jan 15;11:103–112. doi: 10.2147/IDR.S150431

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© 2018 Huang et al. This work is published and licensed by Dove Medical Press Limited

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In vitro dynamic time-kill curves using human exposures of moxalactam, cefotaxime, and cefoperazone/sulbactam against Escherichia coli ATCC25922 and CTX-M-producing E. coli and Klebsiella pneumoniae.

Notes: (A) and (B) show simulated dosing regimens against E. coli ATCC25922; (C) and (D) show simulated dosing regimens against E. coli 3376; (E) and (F) show simulated dosing regimens against K. pneumoniae 2689. The dotted lines indicate the regimens of MOX. The solid lines indicate the regimens of CTX and CFZ/SBT. The lower limit of detection (broken line) was 1.47 log₁₀ CFU/mL.

Abbreviations: ATCC, American Type Culture Collection; CFU, colony forming units; CFZ/SBT, cefoperazone/sulbactam; CTX, cefotaxime; MOX, moxalactam; qd, once-daily; q12h, twice-daily; q8h, thrice-daily.