Table S1.
The pharmacokinetic parameters employed in the study of CTX, CFZ/SBT, and MOX after intravenous infusion
| Drug and dosage | Infusion time (min) | Cmax (µ/mL) | T1/2α (h) | T1/2β (h) | AUC (µ·h/mL) | References |
|---|---|---|---|---|---|---|
| CTX 2g | 30 | 125.86 | 0.2 | 1.43 | 141.93 | 1 |
| MOX 2g | 30 | 219.8 | 0.26 | 2.52 | 536 | 2 |
| MOX 1g | 30 | 81 | 0.28 | 2.56 | 264 | 3 |
| CFZ/SBT 2g (1:1) | 45 (CFZ) | 88.33 | 0.43 | 1.55 | 200.4 | 4 |
| 45 (SBT) | 24.53 | 0.21 | 1.3 | 32.08 | 4 |
Abbreviations: Cmax, peak serum concentration; T1/2α, distribution half-life; T1/2β, elimination half-life; AUC, area under the concentration-time curve. MOX, moxalactam; CTX, cefotaxime; CFZ, cefoperazone; SBT, sulbactam.