Table 2.
Cardiovascular measures and guide ratings of volunteer behavior and mood assessed throughout the session.
| Measure | Low-Dose | High-Dose | High-Dose |
|---|---|---|---|
| Standard-Support | Standard-Support | High-Support | |
| Cardiovascular Measures (peak effects) | |||
| Systolic blood pressure (mm Hg) | 129.38 (2.37) | 145.50 (2.62)*** | 148.54 (3.33)*** |
| Diastolic blood pressure (mm Hg) | 77.44 (1.71) | 83.46 (1.68)** | 85.22 (1.50)*** |
| Heart rate (beats per minute) | 75.74 (1.81) | 91.04 (2.70)*** | 89.96 (2.77)*** |
| Guide Ratings (peak effects, max score=4) | |||
| Overall drug effect | 1.17 (0.09) | 2.68 (0.14)*** | 2.82 (0.10)*** |
| Anxiety or Fearfulness | 0.31 (0.09) | 1.01 (0.17)* | 1.43 (0.33)*** |
| Distance from ordinary reality | 0.75 (0.11) | 2.46 (0.18)*** | 2.43 (0.11)*** |
| Systematized ideas of reference | 0.04 (0.02) | 0.14 (0.05) | 0.17 (0.06)* |
| Yawning | 0.46 (0.15) | 0.76 (0.23) | 1.16 (0.24)* |
| Tearing/Crying | 0.19 (0.11) | 1.02 (0.17) | 2.56 (0.72)*** + |
| Nausea/vomiting | 0.06 (0.04) | 0.44 (0.15)* | 0.5 (0.11)** |
| Joy/intense happiness | 0.46 (0.09) | 1.98 (0.20)*** | 1.8 (0.16)*** |
| Peace/harmony | 0.87 (0.13) | 2.00 (0.20)*** | 1.72 (0.13)*** |
| Psychological Discomfort | 0.14 (0.06) | 0.75 (0.17)** | 0.87 (0.17)*** |
| Physical Distress | 0.07 (0.03) | 0.56 (0.18)** | 0.57 (0.13)** |
Data are means of the peak response in each of the two psilocybin sessions in each participant. Group means with 1 SEM in parentheses (n=25) are shown.
Within a row, asterisks indicate a significant difference from the Low-Dose Standard-Support group (*p<.05, **p<.01, ***p<.001, Planned comparisons), and + indicates a significant difference between the High-Dose High-Support and High-Dose Standard-Support groups (p<.05, Planned comparisons).