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. 2018 Jan 17;8:948. doi: 10.1038/s41598-017-18900-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Antitumor effects of 100 mg/kg of sorafenib daily in NCI-H1299 KRAS wt murine xenografts. *p < 0.05, **p < 0.01, ***p < 0.001. (B) Antitumor effects of 100 mg/kg of sorafenib daily in NCI-H1299 KRAS G12V murine xenografts. ****p < 0.0001 (C) Number of mitoses in six samples per group on days 1 and 7 after the last sorafenib dose in wt and G12V murine xenografts. *p < 0.05. (D) Ki-67 index in six samples per group on days 1 and 7 after the last sorafenib dose in wt and G12V murine xenografts. (E) Number of vessels in six samples per group on days 1 and 7 after the last sorafenib dose in wt and G12V murine xenografts.