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. 2018 Jan 17;8:948. doi: 10.1038/s41598-017-18900-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Sensitivity of KRAS G12V cells treated with sorafenib 1 uM and transfected with each siRNA pool. The log2 of the surviving fraction is shown. (B) Response of G12V cells to sorafenib (1 uM), Wee1 esiRNA (30 nM) or the combination detected by MTS assay. The average of three independent experiments and SD are shown. ***p < 0.001. (C) Response of G12C cells to sorafenib (1 uM), Wee1 esiRNA (30 nM) or the combination detected by MTS assay. The average of three independent experiments and SD are shown. ***p < 0.001. (D) Response of G12V cells to sorafenib (1 uM), MK1775 (150 nM) or the combination detected by MTS assay. The average of three independent experiments and SD are shown. ***p < 0.001. (E) Response of G12C cells to sorafenib (1 uM), MK1775 (150 nM) or the combination detected by MTS assay. The average of three independent experiments and SD are shown. **p < 0.01.