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. 2018 Jan 17;8:1006. doi: 10.1038/s41598-018-19630-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolite abundances in muscle of Manduca sexta and their changes across Diel Time and Age. Female: (a) clustered by Diel Time; (b) clustered by Age. Male: (c) clustered by Diel Time; (d) clustered by Age. The adjusted P values for the comparisons are in Tables S1 and S2. Color in the heatmaps reflects the relative metabolite abundance: red represents metabolite abundances higher than the mean and blue represents metabolite abundances lower than the mean.