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. 2018 Jan 17;8:970. doi: 10.1038/s41598-017-17022-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time course of brain activation during both conditions underlying fast and slow RTs. (A) Parameter estimates of brain activity time courses during SD (orange lines), NP (black lines) for fast RTs (left panels) and slow RTs (right panels). Grey area covers the biological night (16 to 24 h awake). *Areas significantly following the temporal profile of subjective sleepiness during SD; ^†significant difference between speed ranges. (B) Activity overlay on population mean structural image for corresponding brain areas, p < 0.001 uncorrected display for illustration.