Table 2.
Performance of the individual BMs and panels of BMs in the training and testing sets.
| BM | Training set |
Testing set |
||
|---|---|---|---|---|
| AUC | P value | AUC | P value | |
| CEA | 0.71 | <.0001 | 0.70 | <.0001 |
| CA125 | 0.69 | <.0001 | 0.67 | <.0001 |
| CYFRA | 0.55 | .06214 | 0.68 | <.0001 |
| HGF | 0.65 | <.0001 | 0.66 | <.0001 |
| NY-ESO-1 | 0.64 | <.0001 | 0.45 | .09453 |
| 4 BM: CEA, CA125, CYFRA, NY-ESO-1 | 0.75 | <.0001 | 0.77 | <.0001 |
| 5 BM (+HGF) | 0.76 | <.0001 | 0.80 | <.0001 |
Abbreviations: AUC, area under the receiver operator characteristic curve; BM, biomarker; CA125, carbohydrate antigen 125; CEA, carcinoembryonic antigen; CYFRA 21-1, cytokeratin-19 fragment 21-1; HGF, hepatocyte growth factor; NY-ESO-1, New York esophageal cancer-1 antibody.
The listed panel accuracies are from the multiple of the median method calculations.