Fig. 1.

Lesion and NAWM ROIs.

A. Examples of lesion position adjustment (lesion shifting outwards).

Red contour: baseline lesion, green contour: follow-up lesion displayed on follow-up T2 FLAIR image.

B. Example of 4 ROIs used for NAWM.

C. Segmentation of lesional and perilesional white matter displayed on baseline T2 FLAIR image. Red colour represents lesion core, green colour represents lesion “rim” and PLWM shells are yellow and magenta.

D. Example of removing CSF contamination from PLWM displayed on baseline T2 FLAIR image. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)