Table 4.
Univariate Analysis of DFS in Patients with EGFR Active Mutations.
| Genes | Category | N = 43 | 5-year DFS (%) | Univariate Analysis | |
|---|---|---|---|---|---|
| HR (95% CI) | p-value | ||||
| CDKN2B | WT | 27 | 51.6 | ||
| MUT | 16 | 7.1 | 5.618 (1.995–15.827) | 0.001 | |
| CDKN2A | WT | 33 | 54.7 | ||
| MUT | 10 | 14.6 | 1.887 (0.728–4.892) | 0.191 | |
| CDKN1B | WT | 34 | 28.7 | ||
| MUT | 9 | 62.2 | 0.435 (0.123–1.540) | 0.197 | |
| TP53 | WT | 31 | 47.0 | ||
| MUT | 12 | 31.3 | 2.495 (0.956–6.510) | 0.062 | |
| STK11 | WT | 36 | 44.7 | ||
| MUT | 7 | 33.3 | 0.864 (0.246–3.035) | 0.820 | |
| RB1 | WT | 36 | 41.1 | ||
| MUT | 7 | 28.6 | 1.875 (0.601–5.848) | 0.279 | |
| ARID1A | WT | 35 | 24.1 | ||
| MUT | 8 | 100 | 0.136 (0.030–2.492) | 0.056 | |
| FBXW7 | WT | 37 | 30.3 | ||
| MUT | 6 | 62.5 | 0.715 (0.196–2.621) | 0.613 | |
| EGFR* | WT | 37 | 36.5 | ||
| MUT | 6 | 44.4 | 1.737 (0.566–5.329) | 0.334 | |
Note: Only genes mutated in more than six patients were analyzed. *Refers to EGFR non-active mutations, i.e., excluding Exon19 deletion and L858R. DFS, disease-free survival; N, number; HR, hazard ratio; CI, confidence interval; PY, pack-year; WT, wild type; MUT, mutated; Bold values are those with statistical significance of p < 0.05.