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. 2018 Jan 17;8:952. doi: 10.1038/s41598-018-19436-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival curves reveals an early onset and higher rate of mortality in female AT1R mice compared to males. The graph represents the percentage of survival of CTL and AT1R mice of both sexes (M, F) between 0 and 15 months of age (^*p = 0.0013 vs. F CTL, ^†p = 0.0036 vs. M AT1R, Cox regression analysis) (M: CTL N = 107, AT1R N = 91, F: CTL N = 91, AT1R N = 100).