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. 2018 Jan 17;8:952. doi: 10.1038/s41598-018-19436-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ventricular myocyte ionic currents are similarly reduced in male and female AT1R mice in comparison to CTL. (a) Representative ventricular I_Na recorded in CTL and AT1R myocytes of both sexes. Mean data were plotted in a current-voltage (IV) relationships graph demonstrating that the reduction caused by AT1R overexpression is similar in male (M) (CTL: n = 13, AT1R: n = 16) and female (F) (CTL: n = 21, AT1R n = 18). (b) Typical I_CaL traces are presented and mean IV curves show that I_CaL is reduced to the same extent in male and female AT1R mice (M: n = 8, F: n = 10) in comparison to CTL (M: n = 6, F: n = 21). (c) Representative I_peak recordings from all groups are displayed. Mean IV curves also demonstrate that AT1R overexpression similarly reduces total K⁺ current (I_peak) in males (CTL: n = 15, AT1R n = 11) and females (CTL: n = 13, AT1R n = 15). Voltage protocols used for the 3 types of ionic current are shown in insets. Male data for I_Na and I_peak presented in this figure represent a subset of the data presented in^22,24.