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. 2018 Jan 17;8:879. doi: 10.1038/s41598-018-19197-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Barrier enhancing effects of ILO and ILO-PC on human lung macrovascular and microvascular EC and the role of prostacyclin receptor. TER measurements of: (A) Human pulmonary artery EC (HPAEC) and (B) human lung microvascular EC (HLMVEC) stimulated with ILO (0.5 µM) or ILO-PC (0.5 µM). Bar graph depicts quantitative analysis of ILO- and ILO-PC-induced TER changes at the time points after agonist indicated in panels A and B by vertical lines; n = 5; **p < 0.05. (C) HPAEC were pretreated with vehicle or prostacyclin receptor small molecule inhibitor (IPi) followed by stimulation with ILO. (D) HPAEC were pretreated with vehicle or prostacyclin receptor small molecule inhibitor CAY10441 (IPi, 0.2 µM) followed by stimulation with ILO-PC. Bar graph depicts quantitative analysis of IPi inhibitory effects on ILO- and ILO-PC-induced TER elevation at maximal point. Data are expressed as mean ± SD; n = 5; **p < 0.05. Statistical significance by two-way analysis of variance (ANOVA) and Tukey’s post hoc multiple-comparison test.