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. 2018 Jan 17;8:947. doi: 10.1038/s41598-018-19531-7

Table 2.

Multiple cox regression analyses for bladder cancer development.

H.R (95% confidence interval)
Event Person year Incidence* Model 1 Model 2
Age, years
 30–39 479 36,724,384.94 1.30 Ref. Ref.
 40–64 9,493 72,038,460.09 13.18 10.11 (9.22, 11.08) 10.65 (9.71, 11.69)
 ≥65 11,932 17,555,627.37 67.97 52.03 (47.49, 57.01) 52.29 (47.58, 57.47)
Sex
 Male 17,979 64,487,512.03 27.88 Ref. Ref.
 Female 3,925 61,830,960.37 6.35 0.23 (0.22, 0.24) 0.20 (0.19, 0.21)
Smoking status
 Non 9,077 78,119,887.32 11.62 Ref. Ref.
 Ex 5,843 17,281,895.63 33.81 2.90 (2.81, 3.00) 1.32 (1.27, 1.37)
 Current 6,984 30,916,689.45 22.59 1.95 (1.89, 2.01) 1.52 (1.46, 1.57)
BMI, kg/m2
 <18.5 697 4,968,089.15 14.03 0.95 (0.88, 1.02) 0.92 (0.85, 1.00)
 18.5–22.9 7,482 50,015,687.14 14.96 Ref. Ref.
 23.0–24.9 5,964 30,796,378.59 19.37 1.08 (1.05, 1.12) 1.09 (1.06, 1.13)
 25.0–29.9 7,145 35,933,349.62 19.88 1.13 (1.10, 1.17) 1.15 (1.11, 1.19)
 ≥30 616 4,604,967.91 13.38 1.16 (1.07, 1.26) 1.17 (1.05, 1.28)
Alcohol consumption
 Never drinkers 11,796 66,884,498.9 17.64 Ref. Ref.
 Up to 30 g/day 8,059 49,695,192.9 16.22 0.92 (0.89, 0.95) 0.82 (0.79, 0.85)
 More than 30 g/day 1,800 8,250,025.06 21.82 1.24 (1.18, 1.30) 0.79 (0.75, 0.83)
Regularly Exercise
 No 11,479 62,586,593.14 18.34 Ref. Ref.
 Yes 10,283 62,800,931.27 16.37 0.89 (0.87, 0.92) 0.959 (0.933, 0.986)
Hypertension
 No 10,565 93,064,967.88 11.35 Ref. Ref.
 Yes 11,339 33,253,504.52 34.10 3.00 (2.92, 3.08) 1.29 (1.25, 1.33)
Dyslipidemia
 No 15,700 102,023,111.5 15.39 Ref. Ref.
 Yes 6,204 24,295,360.9 25.54 1.66 (1.61, 1.71) 1.11 (1.08, 1.15)
Diabetes
 No 17,298 114,768,614.4 15.07 Ref. Ref.
 Yes 4,606 11,549,857.98 39.88 2.65 (2.57, 2.74) 1.20 (1.16, 1.25)

*All rates are expressed as number per 100,000 person-years.

Univariate model.

Full model of multiple cox regression.