Table 2.

Multiple cox regression analyses for bladder cancer development.

				H.R (95% confidence interval)
	Event	Person year	Incidence*	Model 1†	Model 2‡
Age, years
30–39	479	36,724,384.94	1.30	Ref.	Ref.
40–64	9,493	72,038,460.09	13.18	10.11 (9.22, 11.08)	10.65 (9.71, 11.69)
≥65	11,932	17,555,627.37	67.97	52.03 (47.49, 57.01)	52.29 (47.58, 57.47)
Sex
Male	17,979	64,487,512.03	27.88	Ref.	Ref.
Female	3,925	61,830,960.37	6.35	0.23 (0.22, 0.24)	0.20 (0.19, 0.21)
Smoking status
Non	9,077	78,119,887.32	11.62	Ref.	Ref.
Ex	5,843	17,281,895.63	33.81	2.90 (2.81, 3.00)	1.32 (1.27, 1.37)
Current	6,984	30,916,689.45	22.59	1.95 (1.89, 2.01)	1.52 (1.46, 1.57)
BMI, kg/m2
<18.5	697	4,968,089.15	14.03	0.95 (0.88, 1.02)	0.92 (0.85, 1.00)
18.5–22.9	7,482	50,015,687.14	14.96	Ref.	Ref.
23.0–24.9	5,964	30,796,378.59	19.37	1.08 (1.05, 1.12)	1.09 (1.06, 1.13)
25.0–29.9	7,145	35,933,349.62	19.88	1.13 (1.10, 1.17)	1.15 (1.11, 1.19)
≥30	616	4,604,967.91	13.38	1.16 (1.07, 1.26)	1.17 (1.05, 1.28)
Alcohol consumption
Never drinkers	11,796	66,884,498.9	17.64	Ref.	Ref.
Up to 30 g/day	8,059	49,695,192.9	16.22	0.92 (0.89, 0.95)	0.82 (0.79, 0.85)
More than 30 g/day	1,800	8,250,025.06	21.82	1.24 (1.18, 1.30)	0.79 (0.75, 0.83)
Regularly Exercise
No	11,479	62,586,593.14	18.34	Ref.	Ref.
Yes	10,283	62,800,931.27	16.37	0.89 (0.87, 0.92)	0.959 (0.933, 0.986)
Hypertension
No	10,565	93,064,967.88	11.35	Ref.	Ref.
Yes	11,339	33,253,504.52	34.10	3.00 (2.92, 3.08)	1.29 (1.25, 1.33)
Dyslipidemia
No	15,700	102,023,111.5	15.39	Ref.	Ref.
Yes	6,204	24,295,360.9	25.54	1.66 (1.61, 1.71)	1.11 (1.08, 1.15)
Diabetes
No	17,298	114,768,614.4	15.07	Ref.	Ref.
Yes	4,606	11,549,857.98	39.88	2.65 (2.57, 2.74)	1.20 (1.16, 1.25)

*All rates are expressed as number per 100,000 person-years.

^†Univariate model.

^‡Full model of multiple cox regression.