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. 2018 Jan 17;8:957. doi: 10.1038/s41598-017-19104-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of androgens on the striatal monoaminergic system. DA (A,F), DOPAC to DA ratio (B,G), HVA to DA ratio (C,H), 5-HT (D,I) and 5-HIAA to 5-HT ratio (E,J) were measured by HPLC in the dorsal striatum of C57BL/6J (A–E) and ARKO and WT mice (F–J). Quantitative real-time PCR analysis of striatal mRNA levels of dopamine receptor 1 (Drd1) and 2 (Drd2), postsynaptic density protein 95 (Dlg4), neurofilament, medium polypeptide (Nefm), monoamine oxidase A (Maoa) and B (Maob), catechol-O-methyltransferase (Comt), adenylate cyclase (Adcy5) and olfactory isoform of the stimulatory GTP-binding protein alpha subunit (Gnal) of C57BL/6J (K) and ARKO and WT mice (L). Data in panels A–E and K were analyzed using one-way ANOVA and those in panels F–J and L were analyzed by Student t-test. Data are presented as mean ± SEM. In (A–E), n = 7–9 animals per group; in F–J, n = 10 animals per group; in K, n = 6–9 animals per group; in L, n = 7 animals per group. Statistical significance levels: ^{*, **}P < 0.05 and 0.01. 5-HT serotonin, 5-HIAA hydroxyindolacetic acid, DA dopamine, DOPAC 3,4-dihydroxyphenylacetic acid, HVA homovanillic acid.