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. 2018 Jan 17;8:957. doi: 10.1038/s41598-017-19104-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Androgen deficiency aggravates and treatment with T attenuates the locomotion response to amphetamine. Time course of locomotor-induced behavior after i.p. injection with 3 (A,C) or 0.75 mg/kg (B,D) amphetamine in C57BL/6 J (A,B) and ARKO and WT mice (C,D). The inset graphs show the cumulative beam breaks during 40 min. Locomotor activity evolution was analyzed using two-way repeated measures ANOVA. Cumulative activities were analyzed using one-way ANOVA or Student t-test. Data are presented as mean ± SEM. In (A,B), n = 10–11 animals per group; in (C,D), n = 7–8 animals per group. Statistical significance levels: ^{*, **}P < 0.05 and 0.01 vs. WT. ^#P < 0.05 vs. sham and ORX T. ^$P < 0.05 vs. ORX T.