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. 2018 Jan 17;8:957. doi: 10.1038/s41598-017-19104-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DR2 antagonism inhibits T-induced stimulation of wheel running. Running-wheel activity during baseline (first three days) and after treatment with increasing doses of haloperidol (A), L-741,626 (B) and SCH23390 (C). Percentage of reduction from baseline after exposure to haloperidol (D), L-741,626 (E) and SCH23390 (F). Data in panels D–F were analyzed using two-way repeated measures ANOVA. Data are presented as mean ± SEM. In (A and D), n = 8–11 animals per group; in B and E, n = 6 animals per group; in (C and F), n = 4–6 animals per group. Statistical significance levels: ^{*, **, ***}P < 0.05, 0.01 and 0.001.