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. 2018 Jan 17;8:921. doi: 10.1038/s41598-017-18556-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) K-mean clustering of significant expression differences in the microarray experiment (5% FDR, N = 331 probes). Using k = 4 the first cluster comprises 103 probes downregulated in MCS and AD. The second and forth cluster comprise 66 and 63 probes upregulated in MCS. Cluster 2 genes have an intermediate expression in AD. The 99 probes in cluster three are downregulated in MCS. (B) Pathway studio analysis of genes detected by the gene array analysis: The arrows indicate interaction. HMOX1 is most net-worked.