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. 2018 Jan 17;8:876. doi: 10.1038/s41598-018-19320-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical outcomes in IPA patients treated with optimal voriconazole regimen. (a) IPA Patients treated with optimal voriconazole regimen had similar 90-day survival as patients without IPA. (b) Bilirubin level (median with range) reduced with one weeks of optimal voriconazole regimen treatment. (c) Lesions on pulmonary CT scans (median with interquartile range) resolved obviously with 1–2 weeks of voriconazole treatment.