Table 2.
Risk of recurrent wheezing in Cox regression analysis.
| Risk factors | Recurrent wheezing = 99 | P value | HR | 95% CI |
|---|---|---|---|---|
| Nw (%) | ||||
| Male (Nt = 320) | 73 (73.7) | 0.014 | 2.14 | 1.17–3.91 |
| Caesarean section (Nt = 347) | 63 (63.6) | 0.688 | 1.12 | 0.64–1.95 |
| Allergic history (Nt = 39) | 13 (13.1) | 0.008 | 2.97 | 1.33–6.63 |
| Family history of allergies (Nt = 55) | 19 (19.2) | 0.037 | 2.1 | 1.05–4.22 |
| Mother with bachelor degree or above (Nt = 164) | 36 (36.4) | 0.123 | 1.75 | 0.86–3.56 |
| Living in the city (Nt = 370) | 63 (63.6) | 0.152 | 0.61 | 0.31–1.20 |
| Antibiotic therapy before admission (Nt = 259) | 43 (43.4) | 0.94 | 0.98 | 0.56–1.72 |
| Type of feedings | ||||
| Breastfed (Nt = 213) | NA | NA | NA | NA |
| Formula fed (Nt = 130) | 19 (19.2) | 0.178 | 0.6 | 0.29–1.26 |
| Mixed feedings (Nt = 211) | 31 (31.3) | 0.064 | 0.55 | 0.29–1.04 |
| Detected pathogens | ||||
| RSV only (Nt = 320) | NA | NA | NA | NA |
| RSV–Escherichia coli (Nt = 78) | 16 (16.2) | 0.089 | 1.95 | 0.90–4.19 |
| RSV–Klebsiella pneumoniae (Nt = 76) | 24 (24.2) | 0.002 | 3.15 | 1.51–6.57 |
| RSV–Staphylococcus aureus (Nt = 48) | 20 (20.2) | <0.001 | 4.22 | 2.02–8.83 |
| RSV–Enterobacter cloacae (Nt = 32) | 4 (4.0) | 0.967 | 1.03 | 0.24–4.51 |
| <7 days of age (Nt = 37) | 10 (10.1) | 0.217 | 1.79 | 0.71–4.51 |
| Only child of the family (Nt = 377) | 70 (70.7) | 0.616 | 1.21 | 0.58–2.51 |
| Maternal age <30 years (Nt = 408) | 68 (68.7) | 0.127 | 0.6 | 0.31–1.16 |
Nw = the number of neonates who had the risk among recurrent wheezing neonates.
Nt = the number of neonates who had the risk among total neonates who had follow-up results; NA: not applicable.
HR: hazard ratio; 95% CI: 95% confidence interval. Significant values are in bold.
Cox regression model: the outcomes were adjusted for all the listed risk factors.