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. 2018 Jan 17;8:942. doi: 10.1038/s41598-018-19637-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pools of HSCs and progenitors are increased in Mst1/2-DKO mice. (A) The frequencies of B cells (B220) and myeloid cells (monocytes, Mac1⁺Gr1^lo; neutrophils, Mac1⁺Gr1⁺) in the BM, spleen and PB, and erythroid cells (TER119) in the BM, from mice of the indicated Mst1/2 genotypes are shown. (B) The frequencies of LSK cells, HSCs and cycling HSCs were decreased in BM from Mst1/2-DKO mice. The frequencies of committed progenitors (LMPPs, CLPs, CMPs, GMPs and MEPs) were increased in BM from Mst1/2-DKO mice. (C) The total numbers of colonies produced in M3434 media from cells of mice of each genotype are indicated. Error bars indicate S.E.M. (*p ≤ 0.05, **p ≤ 0.01, n = 4).