Table 2.
Genetic Risk Score (GRS) association with chronotype, food timing and metabolic syndrome components (n = 1,693).
| GRS Score | ||
|---|---|---|
| B (SE) | P | |
| Chronotype | ||
| ME Score | −0.121 (0.058) | 0.037 |
| Metabolic syndrome and insulin resistance | ||
| MetS Score* | 0.001 (0.001) | 0.52 |
| Fasting glucose (mg/dl) | −0.150 (0.160) | 0.35 |
| Triglycerides (mg/dl)* | −0.003 (0.003) | 0.41 |
| HDL-c (mg/dl) | −0.011 (0.122) | 0.93 |
| Systolic Pressure (mmHg) | 0.054 (0.027) | 0.043 |
| Diastolic pressure (mmHg) | 0.028 (0.017) | 0.096 |
| Waist (cm) | 0.101 (0.098) | 0.31 |
| Insulin (µUI/ml)* | 0.001 (0.005) | 0.52 |
| HOMA-IR* | 0.001 (0.002) | 0.62 |
Adjusted by sex and age.
*Values were logarithmically transformed.
B represents change in outcome per each additional copy of the risk (evening) allele.
Abbreviations: ME, morning-evening; MetS, Metabolic Syndrome; HDL-C, High Density Lipoprotein – Cholesterol; HOMA-IR, Homeostatic Model Assessment – Insulin Resistance.